Excessive growth of Virginia market-type peanut affects row visibility and pod yield of peanut. Ten experiments were conducted from 2000 to 2002 in North Carolina to compare peanut response to cyclanilide and prohexadione calcium applied at 50% row closure followed by a repeat application 2 wk later. Cyclanilide and prohexadione calcium increased row visibility in all experiments. Main stem height was shorter at the end of the season when cyclanilide and prohexadione calcium were applied compared with non-treated peanut in all experiments except one. Prohexadione calcium improved row visibility compared with cyclanilide in three experiments and equaled cyclanilide in seven experiments. Main stem height was similar following application of cyclanilide and prohexadione calcium in eight of the 10 experiments. When pooled over experiments, pod yield ranged from 4210 to 4480 kg/ha and did not differ between non-treated peanut and peanut treated with either plant growth regulator. However, prohexadione calcium did increase pod yield of peanut compared with cyclanilide. Results indicate that cyclanilide is not as effective as prohexadione calcium in managing peanut vine growth because of inconsistent enhancement of row visibility and possible negative impacts on pod yield.