Sclerotinia minor, causal agent of Sclerotinia blight, and Cercospora arachidicola, causal agent of early leafspot, are two of the most important pathogens of peanut (Arachis hypogaea L.) in Virginia and North Carolina. Twenty-two Chinese peanut germplasm lines were screened to identify resistance to these two pathogens, and evaluated for agronomic characteristics including seed size, testa color, and pod yield. Germplasm lines with PI numbers 476824 and 476843 exhibited more resistance to S. minor than other Chinese plant introductions, or the U.S. cultivars Florigiant and VA 81B. PI 476823 and PI 476837 were most resistant to C. arachidicola. Resistance to one pathogen was often associated with high levels of susceptibility to the other pathogen. Resistance to S. minor was also associated with undesirable characteristics for large-seeded virginia-type peanuts such as tan testa color and small seed size.