Soil type and weather conditions influenced interactions among peanut cultivars (Florunner, GK 3, and Tifspan), herbicide sequences, and a systemic insecticide (disulfoton). Disulfoton interacted more frequently with cultivars than did herbicides. More interactions occurred in 1974 than in 1973. When peanut yields from the eight studies (on four soil series) were averaged, disulfoton significantly increased peanut yields, especially on Greenville sandy clay loam. On all soil types, except Dothan sandy loam, an insecticide x cultivar interaction occurred at least once accompanied by consistent and significant increases in the yield of Florunner treated with disulfoton. Disulfoton increased yields of Tifspan twice but did not change significantly the yields of GK 3. When compared to a hand-weeded check, herbicides did not decrease average yields significantly unless the sequence terminated with multiple postemergence treatments. Herbicides interacted with cultivars in two of eight experiments, once on Greenville sandy clay loam and once on Tifton sandy loam. In general, GK 3 reacted more to herbicide sequences than did Florunner. Least affected by herbicides was the cultivar Tifspan. An herbicide x insecticide interaction occurred only once (on Dothan sandy loam) when disulfoton increased yields with either the no herbicide treatment or when benefin-vernolate was applied. In general, genetic and environmental factors influenced organoleptic quality and the fatty acid composition of peanut oil much more than did the herbicide or insecticide treatments.